Long-term cognitive deficits are common adverse sequelae of preterm birth ( 1, 2). Similar to human preterm infants, males exposed to hypoxia are especially vulnerable to short-term and long-term deficits in cognition and brain growth. Persistent reductions in hippocampal and cerebellar volumes were found in adult CSH-treated males, whereas regional brain volumes in adult CSH-treated females were indistinguishable from controls. In contrast, CSH-treated females were less impaired. CSH-treated males had impairments in associative learning, spatial memory, and long-term social memory compared with control males. Behavioral assays sensitive to hippocampal function were chosen. Neonatal mice were treated with CSH for 8 d, raised in normoxia thereafter and underwent behavioral testing at 6 wk of age. We now characterize the long-term, sex-specific effects of CSH on cognition and brain growth. Using a chronic, sublethal hypoxia (CSH) mouse model of preterm brain injury, we recently demonstrated acute brain volume loss with an increased male susceptibility to hippocampal volume loss and hypomyelination. Accordingly, you should confirm the accuracy and completeness of all posted information before making any decision related to any data presented on this site.Male sex is an independent risk factor for long-term neurologic deficits in human preterm infants. Owners of assume no responsibility (and expressly disclaim responsibility) for updating this site to keep information current or to ensure the accuracy or completeness of any posted information. Some addresses or other data might no longer be current. Some persons listed might no longer be registered sex offenders and others might have been added. All names presented here were gathered at a past date. No representation is made that the persons listed here are currently on the state's sex offenders registry.
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